ADAMTS4 Antibody
Product Sizes
50ul
£264.00
OAAN00870-50UL
100ul
£379.00
OAAN00870-100UL
200ul
£581.00
OAAN00870-200UL
About this Product
- SKU:
- OAAN00870
- Additional Names:
- ADMP-1; ADAMTS-2; ADAMTS-4
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of this family share several distinct protein modules; including a propeptide region; a metalloproteinase domain; a disintegrin-like domain; and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs; and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease is responsible for the degradation of aggrecan; a major proteoglycan of cartilage; and brevican; a brain-specific extracellular matrix protein. The expression of this gene is upregulated in arthritic disease and this may contribute to disease progression through the degradation of aggrecan. Alternative splicing results in multiple transcript variants; at least one of which encodes an isoform that is proteolytically processed.
- Gene Details:
- ADAM metallopeptidase with thrombospondin type 1 motif 4
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human ADAMTS4
- Isotype:
- IgG
- Molecular Weight:
- 90 kDa
- Protein Details:
- A disintegrin and metalloproteinase with thrombospondin motifs 4
- Purification:
- Affinity purified against immunogen
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
