Neurexin Antibody
Product Sizes
100 uL
£446.00
OAAJ11849-100UL
About this Product
- SKU:
- OAAJ11849
- Additional Names:
- PTHSL2; SCZD17; Hs.22998
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Cell surface protein involved in cell-cell-interactions; exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca2+-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca2+-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise; alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors; a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members; CBLN1 or CBLN2. In vitro; triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom .
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human Neurexin I
- Molecular Weight:
- 150 kDa
- Protein Details:
- Neurexin-1
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
