SLC3A2 Antibody
Product Sizes
100 uL
£446.00
OAAJ07934-100UL
About this Product
- SKU:
- OAAJ07934
- Additional Names:
- 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Required for the function of light chain amino-acid transporters. Involved in sodium-independent; high-affinity transport of large neutral amino acids such as phenylalanine; tyrosine; leucine; arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger; following an antiport mechanism for amino acid transport; influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1; is also involved in the transport of L-DOPA across the blood-brain barrier; and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D;L-homocysteine complexes; and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8; involved in the cellular activity of small molecular weight nitrosothiols; via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1; regulates the transport activity LAT2 in polarized intestinal cells; by generating and delivering intracellular signals. When associated with SLC7A5; plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier.1
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human SLC3A2
- Molecular Weight:
- 67 kDa
- Protein Details:
- 4F2 cell-surface antigen heavy chain
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
