TLR2 Antibody
Product Sizes
100 uL
£446.00
OAAJ07476-100UL
About this Product
- SKU:
- OAAJ07476
- Additional Names:
- TIL4; CD282
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response. May also promote apoptosis in response to lipoproteins. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2); soluble tuberculosis factor (STF); phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6. Acts as a receptor for M.tuberculosis lipoproteins LprA; LprG; LpqH and PhoS1 (pstS1); some lipoproteins are dependent on other coreceptors (TLR1; CD14 and/or CD36). The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen. M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression. Forms activation clusters composed of several receptors depending on the ligand; these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides.
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human TLR2
- Molecular Weight:
- 90 kDa
- Protein Details:
- Toll-like receptor 2
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
