ATF2 Antibody
Product Sizes
100 uL
£446.00
OAAJ07352-100UL
About this Product
- SKU:
- OAAJ07352
- Additional Names:
- HB16; CREB2; TREB7; CREB-2; CRE-BP1
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Transcriptional activator which regulates the transcription of various genes; including those involved in anti-apoptosis; cell growth; and DNA damage response. Dependent on its binding partner; binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus; contributes to global transcription and the DNA damage response; in addition to specific transcriptional activities that are related to cell development; proliferation and death. In the cytoplasm; interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane; thereby impairing mitochondrial membrane potential; inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1; promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human ATF2
- Molecular Weight:
- 56 kDa
- Protein Details:
- Cyclic AMP-dependent transcription factor ATF-2
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
