SUMO1 Antibody
Product Sizes
100 uL
£446.00
OAAJ07327-100UL
About this Product
- SKU:
- OAAJ07327
- Additional Names:
- DAP1; GMP1; PIC1; SMT3; UBL1; OFC10; SENP2; SMT3C; SMT3H3
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I; and can be promoted by E3 ligases such as PIAS1-4; RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport; DNA replication and repair; mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3.
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human SUMO1
- Molecular Weight:
- 12 kDa
- Protein Details:
- Small ubiquitin-related modifier 1
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
