FGFR2 Antibody
Product Sizes
100 uL
£446.00
OAAJ07276-100UL
About this Product
- SKU:
- OAAJ07276
- Additional Names:
- BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR-2; Fibroblast growth factor receptor 2; FLJ98662; JWS; Keratinocyte growth factor receptor; KGFR; KSAM; K-sam; K-SAM; TK14; TK25
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation; differentiation; migration and apoptosis; and in the regulation of embryonic development. Required for normal embryonic patterning; trophoblast function; limb bud development; lung morphogenesis; osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation; proliferation and apoptosis; and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts; but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1; FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1;4;5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2; GAB1; PIK3R1 and SOS1; and mediates activation of RAS; MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling pathway; as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination; internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation; internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptideof human FGFR2
- Molecular Weight:
- 79 kDa
- Protein Details:
- Fibroblast growth factor receptor 2
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
