APBB1 Antibody
Product Sizes
100 uL
£446.00
OAAJ07182-100UL
About this Product
- SKU:
- OAAJ07182
- Additional Names:
- RIR; FE65; MGC:9072
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs); recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60; probably explains its transcription activation activity. Function in association with TSHZ3; SET and HDAC factors as a transcriptional repressor; that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).
- Host:
- Rabbit
- Immunogen:
- Recombinant protein of human APBB1
- Molecular Weight:
- 77 kDa
- Protein Details:
- Amyloid beta A4 precursor protein-binding family B member 1
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
