BUB1B Antibody
Product Sizes
100 uL
£446.00
OAAJ07083-100UL
About this Product
- SKU:
- OAAJ07083
- Additional Names:
- MVA1; SSK1; BUBR1; Bub1A; MAD3L; hBUBR1; BUB1beta
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C; independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human BUB1B
- Molecular Weight:
- 120 kDa
- Protein Details:
- Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
