AIRE Antibody
Product Sizes
100 uL
£446.00
OAAJ07077-100UL
About this Product
- SKU:
- OAAJ07077
- Additional Names:
- APS1; APSI; PGA1; AIRE1; APECED
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Transcriptional regulator that binds to DNA as a dimer or as a tetramer; but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes . Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4'; not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus; which is important for self tolerance and the avoidance of autoimmune reactions.
- Host:
- Rabbit
- Immunogen:
- A synthetic peptideof human AIRE
- Molecular Weight:
- 58 kDa
- Protein Details:
- Autoimmune regulator
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
