BIRC2 Antibody
Product Sizes
100 uL
£446.00
OAAJ06641-100UL
About this Product
- SKU:
- OAAJ06641
- Additional Names:
- API1; MIHB; HIAP2; RNF48; cIAP1; Hiap-2; c-IAP1
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Multi-functional protein which regulates not only caspases and apoptosis; but also modulates inflammatory signaling and immunity; mitogenic kinase signaling; and cell proliferation; as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1; RIPK2; RIPK3; RIPK4; CASP3; CASP7; CASP8; TRAF2; DIABLO/SMAC; MAP3K14/NIK; MAP3K5/ASK1; IKBKG/NEMO; IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway; targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs); Nodlike receptors (NLRs) and RIG-I like receptors (RLRs); collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome; a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human BIRC2
- Molecular Weight:
- 70 kDa
- Protein Details:
- Baculoviral IAP repeat-containing protein 2
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
