DDIT3 Antibody
Product Sizes
100 uL
£446.00
OAAJ06499-100UL
About this Product
- SKU:
- OAAJ06499
- Additional Names:
- CHOP; CEBPZ; CHOP10; CHOP-10; GADD153; AltDDIT3; C/EBPzeta
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family; impairs their association with C/EBP binding sites in the promoter regions; and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3; IL6; IL8; IL23; TNFRSF10B/DR5; PPP1R15A/GADD34; BBC3/PUMA; BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1; ATF4-dependent transcriptional activation of asparagine synthetase (ASNS); CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4; impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
- Host:
- Rabbit
- Immunogen:
- Recombinant proteinof human CHOP
- Molecular Weight:
- 19 kDa
- Protein Details:
- DNA damage-inducible transcript 3 protein
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
