ACKR3 Antibody
Product Sizes
100 uL
£446.00
OAAJ05745-100UL
About this Product
- SKU:
- OAAJ05745
- Additional Names:
- RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment; leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons; thereby adapting their chemokine responsiveness. In glioma cells; transduces signals via MEK/ERK pathway; mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration; adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells; leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates.1
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide
- Molecular Weight:
- 41 kDa
- Protein Details:
- Atypical chemokine receptor 3
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
