APOBEC3D/F Antibody
Product Sizes
100 uL
£446.00
OAAJ05223-100UL
About this Product
- SKU:
- OAAJ05223
- Additional Names:
- APOBEC3DE; APOBEC3E; ARP6
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription; it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA; leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome; along with a deamination-independent mechanism that works prior to the proviral integration; together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide
- Molecular Weight:
- 40 kDa
- Protein Details:
- DNA dC->dU-editing enzyme APOBEC-3D
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
