BRSK1 Antibody
Product Sizes
100 uL
£446.00
OAAJ04262-100UL
About this Product
- SKU:
- OAAJ04262
- Additional Names:
- hSAD1
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B; CDC25C; MAPT/TAU; RIMS1; TUBG1; TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1; acts as a key regulator of polarization of cortical neurons; probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons; leading to down-regulate WEE1 activity in polarized neurons. In neurons; localizes to synaptic vesicles and plays a role in neurotransmitter release; possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131'; leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response; probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1; and inhibition of CDC25B and CDC25C.
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide
- Molecular Weight:
- 87 kDa
- Protein Details:
- Serine/threonine-protein kinase BRSK1
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
