MARK2 Antibody
Product Sizes
100 uL
£446.00
OAAJ04210-100UL
About this Product
- SKU:
- OAAJ04210
- Additional Names:
- EMK1; EMK-1; PAR-1; Par1b; Par-1b
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/mL
- Extra Details:
- Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2; DCX; HDAC7; KIF13B; MAP2; MAP4; MAPT/TAU; and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2; MAP4 and MAPT/TAU at KXGS motifs; causing detachment from microtubules; and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics; possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B; promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7; promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway; probably by mediating phosphorylation of dishevelled proteins (DVL1; DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide
- Molecular Weight:
- 85 kDa
- Protein Details:
- Serine/threonine-protein kinase MARK2
- Purification:
- Immunogen affinity chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at +4C. For long term storage; aliquot and store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
