EP300 Antibody
Product Sizes
100 ul
£446.00
OAAJ02164-100UL
About this Product
- SKU:
- OAAJ02164
- Additional Names:
- p300; KAT3B; MKHK2; RSTS2
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- p300 is a histone acetyltransferase and transcriptional co-activator that regulates transcription via chromatin remodeling. Acetylates all four core histones in nucleosomes. Related to CPB (CREB-binding protein); and like CPB can stimulate transcription through activation of CREB. Specifically inhibited by the adenovirus oncoprotein E1A. A co-activator of HIF1A (hypoxia-inducible factor 1 alpha); and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Methylated at R580 and R604 in the KIX domain by CARM1; which blocks association with CREB; inhibits CREB signaling and activates the apoptotic response. Also methylated at R2142 by CARM1; which impairs interaction with NCoA2.
- Gene Details:
- E1A binding protein p300
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human p300
- Molecular Weight:
- 264 kDa
- Purification:
- Immunogen affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Stable for 12 months from date of receipt.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
