BCAR3 Antibody
Product Sizes
100 ul
£446.00
OAAJ02077-100UL
About this Product
- SKU:
- OAAJ02077
- Additional Names:
- MIG7; NSP2; AND-34; SH2D3B
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance; activates Rac; PAK1; and the cyclin D1. Can accelerate the degradation of IRS-1; thus regulating signaling through the insulin receptor. When overexpressed; it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described.
- Gene Details:
- breast cancer anti-estrogen resistance 3
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human BCAR3
- Molecular Weight:
- 92 kDa
- Purification:
- Immunogen affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Stable for 12 months from date of receipt.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
