APAF1 Antibody
Product Sizes
100 ul
£446.00
OAAJ01716-100UL
About this Product
- SKU:
- OAAJ01716
- Additional Names:
- CED4; APAF-1
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- APAF Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3); leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. Induced by E2F and p53 in apoptotic neurons. Monomer. Oligomerizes upon binding of cytochrome c and dATP. Oligomeric Apaf-1 and pro-caspase-9 bind to each other via their respective NH2-terminal CARD domains and consecutively mature caspase-9 is released from the complex. Pro-caspase-3 is recruited into the Apaf-1-pro-caspase-9 complex via interaction with pro-caspase-9. Interacts with APIP. 6 isoforms of the human protein are produced by alternative splicing.
- Gene Details:
- apoptotic peptidase activating factor 1
- Host:
- Rabbit
- Immunogen:
- A synthesized peptide derived from human APAF1
- Molecular Weight:
- 27 kDa
- Purification:
- Affinity-chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at -20C. Stable for 12 months from date of receipt.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
