Anti-AEG1 Antibody
Product Sizes
100ug
£597.00
OAAI00784-100UG
About this Product
- SKU:
- OAAI00784
- Additional Names:
- 3D3;3D3/LYRIC;AEG1;AEG-1;astrocyte elevated gene 1;astrocyte elevated gene-1 protein;LYRIC;LYRIC/3D3;lysine-rich CEACAM1 co-isolated protein;metastasis adhesion protein;protein LYRIC.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- AEG1 (Astrocyte elevated gene 1); also called MTDH (Metadherin); or L LYsine-RIch CEACAM1 co-isolated (LYRIC); is 582 aa single transmembrane domain (TMD) protein. It is widely expressed and highly conserved between species. It is recruited during the matuRation of the tight junction complex and co-localizes with tight junction proteins ZO-1 and occludin in polarized epithelial cells. AEG-1 is involved in several crucial aspects of tumor progression; including transformation; evasion of apoptosis; invasion; metastasis; and chemoresistance. Overexpression of AEG-1 is frequently observed in melanoma; glioma; neuroblastoma; and carcinomas of breast; prostate; liver; and esophagus and is correlated with poor clinical outcomes. AEG-1 functions as a downstream mediator of the transforming activity of oncogenic Ha-Ras and c-Myc.
Furthermore; AEG-1 overexpression activates the PI3K/Akt; nuclear factor κB (NFκB); and Wnt/beta-catenin signaling pathways to stimulate prolifeRation; invasion; cell survival; and chemoresistance. The lung-homing domain of AEG-1 also mediates the adhesion of tumor cells to the vasculature of distant organs and promotes metastasis. These findings sμggest that therapeutic targeting of AEG-1 may simultaneously suppress tumor growth; block metastasis; and enhance the efficacy of chemotherapeutic treatments. - Gene Details:
- metadherin
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide derived from a phosphrylation site of serine 568 surrounding the epitope -TSWESPKQI-of human AEG1. This sequence is identical to human; mouse; rat and bovine.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
