Anti-ZBTB4 Antibody
Product Sizes
100ug
£532.00
OAAI00757-100UG
About this Product
- SKU:
- OAAI00757
- Additional Names:
- KAISO-L1;KAISO-like zinc finger protein 1;zinc finger and BTB domain-containing protein 4;ZNF903.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Zink finger and BTB domain coating 4 (ZBTB4) is a transcriptional repressor protein; which is associated with the Sin3/histone deacetylase co-repressor and represses expression of P21CIP1 as part of a heterodimeric complex with Miz1.
In vivo; expression of ZBTB4 is downregulated in advanced stages of multiple Human tumours. In cell culture; depletion of ZBTB4 promotes cell cycle arrest in response to activation of p53 and suppresses apoptosis throμgh regulation of P21CIP1; thereby promoting long-term cell survival. ZBTB4 is a critical determinant of the cellular response to p53 activation and reinforce the notion that p21Cip1 can provide an essential survival signal in cells with activated p53. - Gene Details:
- zinc finger and BTB domain containing 4
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the N-terminus of human ZBTB4 protein. This sequence is identical to human; mouse; rat; bovine; canis etc.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
