Anti-Rho-GDI Antibody
Product Sizes
100ug
£608.00
OAAI00735-100UG
About this Product
- SKU:
- OAAI00735
- Additional Names:
- epididymis secretory sperm binding protein Li 47e;GDIA1;GDP-dissociation inhibitor; aplysia RAS-related 1;HEL-S-47e;NPHS8;Rho GDP dissociation inhibitor (GDI) alpha;rho GDP-dissociation inhibitor 1;RHOGDI;RHOGDI-1.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Rho GTPases (Rac; Rho; and Cdc42) play important roles in regulating cell function throμgh their ability to coordinate the actin cytoskeleton; modulate the formation of signaling reactive oxidant species; and control gene transcription. Activation of Rho GTPase signaling pathways requires the regulated release of Rho GTPases from Rho-GDI complexes; followed by their reuptake after membrane cycling. There are two isoforms; Rho-GDI alpha and Rho-GDI beta play synergistic roles in cell migRation and development by modulating activation cycle of the Rho proteins. Src kinase binds and phosphorylates RhoGDI both in vitro and in vivo at Tyr156 which causes a dramatic decrease in the ability of RhoGDI to form a complex with RhoA; Rac1; or Cdc42. Src-mediated RhoGDI phosphorylation is a novel physiological mechanism for regulating Rho GTPase cytosol membrane-cycling and activity.
- Gene Details:
- Rho GDP dissociation inhibitor alpha
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide surrounding the epitope - CRPEEYEFL- with a phosphorylation site at Tyrosine 156 of human Rho-GDI alpha protein. This sequence is identical among human; rat; mouse; bovine; chicken and dog.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
