Anti-p15INK4b Antibody
Product Sizes
100ug
£511.00
OAAI00734-100UG
About this Product
- SKU:
- OAAI00734
- Additional Names:
- CDK inhibitory protein;CDK4B inhibitor;CDK4I;cyclin-dependent kinase 4 inhibitor B;cyclin-dependent kinase inhibitor 2B (p15; inhibits CDK4);cyclin-dependent kinases 4 and 6 binding protein;INK4B;MTS2;MTS-2;multiple tumor suppressor 2;p14_CDK inhibitor;p14_INK4B;p14-INK4b;P15;p15 CDK inhibitor;p15_INK4B;p15INK4b;p15-INK4b;TP15.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Cyclin-dependent kinases (CDKs) are activated in part by forming complexes with cyclins. For example; CDK4 and CDK6 associate with the D-type cyclins and phosphorylate the retinoblastoma protein. This phosphorylation is a necessary event for cells to enter S-phase. The inhibitors of CDK4 (INK4) family include p15INK4B; p16INK4A; p18INK4C and p19INK4D. p18 has been shown to function as a aploinsufficient tumor suppressor in vivo. All INK4 proteins are composed of 32 amino acid ankyrin motifs and selectively inhibit CDK4/6 activity. Mutational analyses of p18 implicate the third and the amino-terminal portion of the fourth ankyrin repeat in mediating binding to CDK4/6. The interaction of INK4 family members can be a binary complex with CDK4/6 or ternary complex with cyclin D-bound CDK4/6 and ultimately results in the inhibition of cell cycle progression. The gene encoding p15INK4B is often silenced by hypermethylation in acute myeloid leukemia and deleted in acute lymphocytic leukemia.
- Gene Details:
- cyclin dependent kinase inhibitor 2B
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the C-terminus of Mouse p15INK4b. This sequence is identical to human; rat and mouse.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
