Anti-Neurofibromin Antibody
Product Sizes
100ug
£522.00
OAAI00706-100UG
About this Product
- SKU:
- OAAI00706
- Additional Names:
- neurofibromatosis 1;neurofibromatosis-related protein NF-1;neurofibromin;NFNS;truncated neurofibromin 1;VRNF;WSS.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- The neurofibromatosis type 1 (NF1) tumor suppressor (neurofibromin) is thoμght to play crucial roles in cellular Ras- and cAMP-dependent kinase (PKA)-associated signals. The absence of or alteRation of the neurofibromin protein may lead to neurofibromatosis disease. Recently; a cellular neurofibromin-associating protein; NG;NG-dimethylarginine dimethylaminohydrolase (DDAH)has been identified as a cellular NO/NOS regulator which increases PKA phosphorylation of native neurofibromin in a dose-dependent manner. The PKA accessibility of neurofibromin regulated via DDAH interaction may modulate the cellular function of neurofibromin that is implicated in NF1-related pathogenesis.
- Gene Details:
- neurofibromin 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide surrounding the epitope -PTSPY- without phosphorylation at human neurofibromin. This sequence is identical among human; rat; mouse; chicken; bovine and dog.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
