Anti-MBP Antibody
Product Sizes
100ug
£522.00
OAAI00702-100UG
About this Product
- SKU:
- OAAI00702
- Additional Names:
- Golli-MBP;myelin A1 protein;myelin basic protein;myelin membrane encephalitogenic protein;proline-rich proteoglycan 2.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However; MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP; spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes. MBP has a role in both the formation and the stabilization of this compact multilayer arrangement of bilayers. In vitro; MBP is suitable as a substrate for numerous protein kinases; including the ERK and p38 MAP kinases that phosphorylate MBP at T98.
- Gene Details:
- myelin basic protein
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide with a phosphorylation site at Threonine 98. This sequence is identical among human; rat; mouse.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
