Anti-AMPK Alpha Antibody
Product Sizes
100ug
£565.00
OAAI00694-100UG
About this Product
- SKU:
- OAAI00694
- Additional Names:
- 5'-AMP-activated protein kinase catalytic subunit alpha-1;5'-AMP-activated protein kinase; catalytic alpha-1 chain;ACACA kinase;acetyl-CoA carboxylase kinase;AMP -activate kinase alpha 1 subunit;AMP-activated protein kinase; catalytic; alpha-1;AMPK;AMPK alpha 1;AMPK subunit alpha-1;AMPK; alpha; 1;AMPKa1;HMGCR kinase;hydroxymethylglutaryl-CoA reductase kinase;protein kinase; AMP-activated; alpha 1 catalytic subunit;tau-protein kinase PRKAA1.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy balance at both the cellular and the whole body levels. Once activated; it affects a metabolic switch from an anabolic to a catabolic state; both by acutely phosphorylating metabolic enzymes and; in the longer term; by regulating gene expression. AMPK is a heterotrimeric complex composed of a catalytic alpha subunit and regulatory beta and γ subunits.
Binding APM to the beta domains triggers increased phosphorylation at Thr172 on the activation loop of the alpha subunit.
AMP Phosphorylation at Thr172 is catalyzed by the tumor suppressor kinase LKB1 or CaMKK-beta; TGF-beta activated kinase-1 (TAK1). AMPKalpha is also phosphorylated at Thr258 and Ser485 (for alpha1; Ser491 for alpha2). - Gene Details:
- protein kinase AMP-activated catalytic subunit alpha 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide surrounding to the epitope -LRTSC- with a phosphorylation site at Thr 172 of AMPK alpha protein from human origin. It is identical among human; mouse; rat; chicken; bovine; dog; and insect species.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
