Anti-Desmoglein 3 Antibody
Product Sizes
100ug
£532.00
OAAI00679-100UG
About this Product
- SKU:
- OAAI00679
- Additional Names:
- 130 kDa pemphigus vulgaris antigen;ABOLM;cadherin family member 6;CDHF6;desmoglein-3;PVA.
- translate.label.attr.clone:
- ZY043
- Clonality:
- Monoclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Dsg3 and Dsg1 are members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keRatinocytes; the former distributes primarily in the deeper epidermis; whereas the latter is localized to the superficial epidermis. This distribution profile of these target antigens;Dsg3 and Dsg1; of PV (Pemphigus Vulgaris ) and pemphigus foliaceus autoantibodies explains the characteristic clinical features and histopathological localization of acantholysis in their respective diseases. Dsg3 plays important roles in cell-cell adhesion in PV-autoimmune disease as well as in Human squamous cell cancer. The level of Dsg3 can be used as a read-out of pathogenic changes.
- Gene Details:
- desmoglein 3
- Host:
- Mouse
- Immunogen:
- The recombinant protein of human Desmoglein-3 extracellular domain.
- Isotype:
- Mouse IgG1
- Purification:
- The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
