Anti- Beta -Catenin Antibody
Product Sizes
100ug
£532.00
OAAI00596-100UG
About this Product
- SKU:
- OAAI00596
- Additional Names:
- armadillo;catenin (cadherin-associated protein); beta 1; 88kDa;catenin beta-1;CTNNB;EVR7;MRD19;NEDSDV.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Beta-catenin is a cytosolic; 88 kDa; 781 amino acid protein belongs to the beta-catenin family. The N-terminus domain; containing the binding site and the phosphorylation sites. Beta-Catenin serves as a link between cytoskeleton actin and transmembrane cadherin(s). It is believed to contribute to tight cell-to-cell adhesion. It can enter the nucleus and interact with the TCF/LEF family of transcription factors; initiating gene expression. Normally; beta-catenin transcriptional activity is suppressed by a Ser/Thr kinase termed GSK3beta and/or Casein Kinase I (CK1). Kinases are constitutively active and phosphorylates beta-catenin at multiple sites; including S33 and S37; Y96; Y228; Y280 etc. Phosphorylation of beta-catenin targets the molecule for degradation via a ubiquination-mediated pathway. GSK3beta activity can be blocked by upstream signaling events such as Wnt-Frizzled interaction. This inhibits GSK3beta; allowing unphosphorylated beta-catenin to enter the nucleus and initiate gene activation. The phosphorylation of beta-catenin might contribute to tumorigenesis.
- Gene Details:
- catenin beta 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide CQS YLD D-S-GIH-S-GAT of human beta-catenin.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
