Anti-GSK-3 Beta Antibody
Product Sizes
100ug
£413.00
OAAI00558-100UG
About this Product
- SKU:
- OAAI00558
- Additional Names:
- glycogen synthase kinase-3 beta;GSK-3 beta;serine/threonine-protein kinase GSK3B.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Glycogen Synthase Kinase-3beta (GSK-3beta) is a serine/threonine kinase that affects glycogen metabolism by phosphorylating and down-regulating the activity of muscle glycogen synthase. Growth factor (such as Insulin) binds to its receptor; recruits PKB/AKT kinase to phosphorylate GSK-3beta on Serine 9; which prevents GSK-3beta from phosphorylating glycogen synthase. In contrast; the phosphorylation of tyrosine 216 in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3beta is also involved in Wnt signaling pathway where it forms a complex with axin; beta-catenin and adenomatous polyposis coli (APC) protein; thus the GSK-3beta inhibitor is considered as a potential approach in Alzheimer's Disease (AD) treatment.
- Gene Details:
- glycogen synthase kinase 3 beta
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the C-terminus of GSK-3beta protein. This sequence is identical among human; mouse; rat; bovine; dog and chicken species.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
