Anti-CD136 Phospho-specific Antibody
Product Sizes
100ug
£532.00
OAAI00530-100UG
About this Product
- SKU:
- OAAI00530
- Additional Names:
- CD136;CDw136;c-met-related tyrosine kinase;macrophage-stimulating protein receptor;MSP receptor;NPCA3;p185-Ron;PTK8;PTK8 protein tyrosine kinase 8;RON;S13 avian erythroblastosis oncogene homolog;S13 erythroblastosis oncogene homolog;SEA.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- CD136; a transmembrane receptor tyrosine kinase; also known as Macrophage stimulating 1 receptor (MST1R) and RON (Recepteur d'origine nantais); is a member of the MET proto-oncogene family (63% homology); and is the receptor for macrophage-stimulating protein (MSP); a multifunctional cytokine that regulates cell adhesion; motility; growth; and survival.
Binding of MSP to CD136 stimulates tyrosine phosphorylation on Tyr 1238 and Tyr 1239. This phosphorylation leads to a upregulation of CD136 catalytic activity and subsequent activation of downstream signaling molecules. In addition; CD136 contains putative autophosphorylation sites on Tyr 1353 and Tyr 1360. RON mediates multiple signaling cascades; such as MAPK; PI3K/AKT; FAK pathways. CD136 activation can also significantly increase C-Src activity. CD136 is a disulfide-linked 180kD heterodimer composed of a 35kD alpha chain and a 150kD beta chain; and is mainly expressed in cells of epithelial origin. CD136 is thoμght to play a role in early embryonic development and in the inflammatory response as well as implicated in the progression and metastasis of tumors including those of the breast and colon. - Gene Details:
- macrophage stimulating 1 receptor
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide containing epitope -EPYYS- with a single phosphorylation sites Y1238 of the human CD136.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
