Anti-SPHK2 Polyclonal Antibody
Product Sizes
100ug
£413.00
OAAI00508-100UG
About this Product
- SKU:
- OAAI00508
- Additional Names:
- SK 2;SK-2;sphingosine kinase 2;SPK 2;SPK-2.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Sphinogosine Kinase has two isozymes (SPHK1 and SPHK2) that catalyze the phosphorylation of sphingosine into sphingosine1-phosphate (S1P). Sphingosine 1-phosphate mediates many cellular processes including migRation; prolifeRation and apoptosis; and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis.
SPHK is an important signaling enzyme which is activated by diverse agents; including growth factors that signal throμgh receptor tyrosine kinase; agents activating G protein-coupled receptors; and immunoglobulin receptors. It also plays a role in breast cancer prolifeRation and chemoresistance. SPHK1 and SPHK2 are ubiquitously expressed. SphK-1 has been shown to mediate cell growth; prevention of apoptosis; and cellular transformation; and is upregulated in a variety of Human tumors.
In contrast; SphK-2 increases apoptosis; and may be responsible for phosphorylating and activating the immunosuppressive drμg FTY720. - Gene Details:
- sphingosine kinase 2
- Host:
- Rabbit
- Immunogen:
- A full length of SPHK2 recombinant protein was used as an immunogen.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
