Anti-LRP6 Phospho-specific Antibody
Product Sizes
100ug
£457.00
OAAI00462-100UG
About this Product
- SKU:
- OAAI00462
- Additional Names:
- ADCAD2;low-density lipoprotein receptor-related protein 6;LRP-6;STHAG7.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Low-desnsity lipoprotein receptor (LDLR)-related protein 6 (LRP6) is a member of the LDLR family which consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. LRP5 cuases several Human diseases including bone mineral density variability1; endosteal hyperostosis; autosomal dominant osteopetrosis type I etc. The V171 mutation in LRP5 causes high bone density by impairing the action of a normal antagonist of the Wnt pathway and thus increasing Wnt signaling. The activity of LRP5 and LRP6 can be inhibited by binding of some members of Dickkopf (DKK) family proteins. Upon stimulation with Wnt; LRP5 and LRP6 are phosphorylated at multiple sites including Thr 1479; Ser 1490 and Thr 1492 by kinases such as GSK-3 and CK1.
- Gene Details:
- LDL receptor related protein 6
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the epitope KGTYF at a phosphorylation threonine1479 in LRP6 protein
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
