Anti-Fibulin 2 Polyclonal Antibody
Product Sizes
100ug
£435.00
OAAI00422-100UG
About this Product
- SKU:
- OAAI00422
- Additional Names:
- FIBL-2;fibulin-2.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Fibulin-2; a 1221 amino acids protein containing 26-residue signal peptide; is an extracellular matrix protein expressed by normal epithelia. Study by immunofluorescence localizations using Mouse tissue; Fibulin-2 was extracellular localized in basement membrane and other connective tissue compartments. By Immunohistochemistry; Fibulin-2 was expressed in fibrobasts but not in several tumor cell lines. In the serum level of fibulin-2 is 1;000-fold lower than that of fibulin-1. Fibulin-2 was found to be down-regulated in several breast cancer cell lines as well as the decreased expression in breast cancer tissue samples. Re-introduction of Fibulin-2 into breast cancer cell lines that do not express Fibulin-2 reduced cancer cell motility and invasion in vitro but had no effect on cell growth and adhesion properties.
Together with evidence that Fibulin-2 contributes to wound healing and inhibits smooth muscle cell migRation. The loss of Fibulin-2 expression may facilitate migRation and invasion in breast cancer. - Gene Details:
- fibulin 2
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the 1140-1165aa of Fibulin-2 protein. This sequence is identical to mouse; human and rat
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
