Anti-IRAK-4 Antibody
Product Sizes
100ug
£435.00
OAAI00415-100UG
About this Product
- SKU:
- OAAI00415
- Additional Names:
- IMD67;interleukin-1 receptor-associated kinase 4;IPD1;IRAK-4;NY-REN-64;REN64;renal carcinoma antigen NY-REN-64.
- translate.label.attr.clone:
- A8A8
- Clonality:
- Monoclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- IRAK (IL-1 associated serine/threonine kinase) is a critical regulator of Interleukin-1 (IL-1) induced activation of the NFkappaB pathway. IL-1 stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor; where IRAK is phosphorylated; ubiquitinated; and eventually degraded. There are four members (IRAK1; IRAK2; IRAK3/IRAK-M and IRAK4). IRAK-4; recently found another IRAK family member necessary for the IL-1 pathway; is able to phosphorylate IRAK in vitro sμggests that IRAK-4 might be the IRAK kinase.
IRAK4 is required for the efficient recruitment of IRAK to the IL-1 receptor complex. - Gene Details:
- interleukin 1 receptor associated kinase 4
- Host:
- Mouse
- Immunogen:
- A synthetic peptide surrounding to the epitope -VMTSR- with a phosphorylation site at Thr345 of human IRAK-4 protein. This sequence is identical among human; mouse; bovine and dog.
- Isotype:
- IgG1
- Purification:
- The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
