Anti-Cdk8 Polyclonal Antibody
Product Sizes
100ug
£457.00
OAAI00300-100UG
About this Product
- SKU:
- OAAI00300
- Additional Names:
- CDK8 protein kinase;cell division protein kinase 8;cyclin-dependent kinase 8;IDDHBA;K35;mediator complex subunit CDK8;mediator of RNA polymerase II transcription subunit CDK8;protein kinase K35.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- A family of proteins designated as cdks belongs to the protein kinase superfamily. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28; and Schizosaccharomyces pombe cdc2; and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase; which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase; as well as CDK4; has been shown to phosphorylate; and thus regulate the activity of; tumor suppressor protein Rb.
Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants; encoding the same protein; have been identified. CDK8 kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex; which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH); thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. - Gene Details:
- cyclin dependent kinase 8
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide derived from C-terminus of human cdk8 protein. This sequence is identical to human; mouse and rat.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
