Anti-Caspase 6 Polyclonal Antibody
Product Sizes
100ug
£597.00
OAAI00296-100UG
About this Product
- SKU:
- OAAI00296
- Additional Names:
- apoptotic protease MCH-2;caspase 6; apoptosis-related cysteine peptidase;caspase 6; apoptosis-related cysteine protease;caspase-6;MCH2.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Caspases belong to the cysteine-aspartic acid protease (Caspase) family which plays a major role in the transduction of the apoptotic signal and execution of apoptosis in mammalian cells. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits; large and small; that dimerize to form the active enzyme. This protein could be processed by caspases 7; 8 and 10; and is thoμght to function as a downstream. Caspase 3 (CPP32) and Caspase 6 (Mch2) are the major active caspases in apoptotic cells; and are activated in response to distinct apoptosis-inducing stimuli and in all cell lines analyzed. Both CPP32 and Mch2 are present in apoptotic cells as multiple active species. Caspase-6 cleaves nuclear mitotic appaRatus protein (NuMA) and mediates the shrinkage and fragmentation of nuclei.
- Gene Details:
- caspase 6
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide derived from C-terminus of human Caspase 6 protein. This sequence is identical to human rat and mouse species
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
