Anti-C-Abl Monoclonal Antibody
Product Sizes
100ug
£630.00
OAAI00281-100UG
About this Product
- SKU:
- OAAI00281
- Additional Names:
- Abelson tyrosine-protein kinase 1;ABL;ABL protooncogene 1 nonreceptor tyrosine kinase;bcr/abl;bcr/c-abl oncogene protein;BCR-ABL;c-ABL;c-abl oncogene 1; receptor tyrosine kinase;c-ABL1;CHDSKM;JTK7;p150;proto-oncogene c-Abl;proto-oncogene tyrosine-protein kinase ABL1;truncated ABL protooncogene 1 nonreceptor tyrosine kinase;tyrosine-protein kinase ABL1;v-abl;v-abl Abelson murine leukemia viral oncogene homolog 1.
- translate.label.attr.clone:
- ABM328
- Clonality:
- Monoclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- The c-Abl proto-oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. It is activated by certain DNA-damaging agents and regulates induction of the stress-activated c-Jun N-terminal protein kinase (SAPK). In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias; the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c-Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the geneRation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
- Gene Details:
- ABL proto-oncogene 1; non-receptor tyrosine kinase
- Host:
- Mouse
- Immunogen:
- The synthetic peptide corresponding to SH2 domain of c-Abl protein.
- Isotype:
- IgG1
- Molecular Weight:
- 120-140
- Purification:
- The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
