Anti-P57/Kip2 Monoclonal Antibody
Product Sizes
100ug
£522.00
OAAI00277-100UG
About this Product
- SKU:
- OAAI00277
- Additional Names:
- BWCR;BWS;cyclin-dependent kinase inhibitor 1C;cyclin-dependent kinase inhibitor 1C (p57; Kip2);cyclin-dependent kinase inhibitor p57;KIP2;p57;p57Kip2;WBS.
- translate.label.attr.clone:
- KP10
- Clonality:
- Monoclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- p57/Kip 2 (or CDKN 1C) is a tight-binding strong inhibitor of several G1 cycline/Cdk complexes and a negative regulator of cell prolifeRation. The gene is a tumor suppressor which is located on chromosome 11p15.5. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndrome (BWS). Several types of childhood tumors including Wilms' tumor; adrenocortical carcinoma and rhabdomyosarcoma display a specific loss of maternal 11p15 alleles; sμggesting that genomic imprinting plays an important part. This region also contains two other imprinted genes; insulin like growth factor II (IGF II) and H19; both of which seem to be implicated in adrenal neoplasms.
- Gene Details:
- cyclin dependent kinase inhibitor 1C
- Host:
- Mouse
- Immunogen:
- Recombinant human p57/Kip2 protein.
- Isotype:
- IgG2b
- Purification:
- The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
