Anti-Cyclin B1 Polyclonal Antibody
Product Sizes
100ug
£532.00
OAAI00233-100UG
About this Product
- SKU:
- OAAI00233
- Additional Names:
- CCNB;G2/mitotic-specific cyclin-B1.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Cyclin B1 is a regulatory protein involved in mitosis. Like all cyclins; levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis; a large amount of cyclin B1 is present in the cell; but it is inactive due to phosphorylation of Cdk1 by the Wee1 kinase. The complex is activated by dephosphorylation by the phosphatase Cdc25. Once cyclin B1-Cdk1 is activated; it remains stably active for the rest of mitosis. At the end of mitosis; cyclin B1 is targeted for degradation by the APC throμgh its APC localization sequence permitting to exit mitosis. Cyclin B1/Cdc2 complexes; which appear to be constitutively cytoplasmic during interphase; actually shuttle continually into and out of the nucleus; with the Rate of nuclear export exceeding the import Rate. Cell growth prior to cell division is restricted by the activity of cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complexes. Cdk1/cyclin B1 activity shields Human cells against extrinsic death stimuli and unravel the molecular details of the cross talk between cell cycle and extrinsic apoptotic pathways.
- Gene Details:
- cyclin B1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide derived from C-terminus of human cyclin B1 protein.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
