Anti-C-erbB-2/HER-2 Antibody
Product Sizes
100ug
£467.00
OAAI00099-100UG
About this Product
- SKU:
- OAAI00099
- Additional Names:
- CD340;c-erb B2/neu protein;HER2;HER-2;HER-2/neu;herstatin;human epidermal growth factor receptor 2;metastatic lymph node gene 19 protein;MLN 19;NEU;neuro/glioblastoma derived oncogene homolog;neuroblastoma/glioblastoma derived oncogene homolog;NGL;proto-oncogene c-ErbB-2;proto-oncogene Neu;receptor tyrosine-protein kinase erbB-2;TKR1;tyrosine kinase-type cell surface receptor HER2;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2;v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog;VSCN2.
- translate.label.attr.clone:
- S495
- Clonality:
- Monoclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Oncoprotein Her-2/Neu/ c-erbB-2 belongs to one of the four members of the ErbB receptor family. They are transmembrane receptor-like tyrosine kinases which can be autophosphorylated without ligand binding process when it is overexpressed in breast cancers. Her2 is an important biomarker in breast cancer diagnosis. The antibodies/ heregulin can suppress phosphorylation of HER2 on tyrosine Y1248. Endogenous anti-HER2 antibodies can effectively suppress HER2 kinase activity and downstream signaling to inhibit the transformed phenotype of HER2-expressing tumor cells. Thus; anti-Her2 antibodies have been used widely in the treatment of the breast cancer and other carcinomas.
- Gene Details:
- erb-b2 receptor tyrosine kinase 2
- Host:
- Mouse
- Immunogen:
- A synthetic peptide corresponding to the C-terminus of Her2 protein. This sequence is identical in human; mouse; and ra
- Isotype:
- IgG1
- Purification:
- The mouse IgG is purified by Protein A-Affinity Chromatography according to Isotyping
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
