Anti-TGF- Beta R1 Polyclonal Antibody
Product Sizes
100ug
£532.00
OAAI00094-100UG
About this Product
- SKU:
- OAAI00094
- Additional Names:
- AAT5;activin A receptor type II-like kinase; 53kDa;activin A receptor type II-like protein kinase of 53kD;activin receptor-like kinase 5;ACVRLK4;ALK5;ALK-5;ESS1;LDS1;LDS1A;LDS2A;MSSE;mutant transforming growth factor beta receptor I;serine/threonine-protein kinase receptor R4;SKR4;tbetaR-I;TBR-i;TBRI;TGF-beta receptor type-1;TGFR-1;transforming growth factor beta receptor I;transforming growth factor-beta receptor type I.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Transforming growth factor beta isoforms (TGF-beta1; 2; 3) play vital roles in regulating cellular growth and differentiation; and they signal throμgh a highly restricted subset of receptors known as TGF-beta type I receptor (TbetaR-I) and TGF-beta type II receptor(TbetaR-II). TGF-beta's specificity for TbetaR-I has been proposed to arise from its pre-helix extension; a five-residue loop that binds in the cleft between TGF-beta and TbetaR-II. TGF-beta binds with high affinity to the type II receptor; a transmembrane protein with a cytoplasmic serine/threonine kinase domain; which requires both its kinase activity and association with another TGF beta-binding protein; the type I receptor; to signal growth inhibition and early gene responses. Receptors I and II associate as interdependent components of a heteromeric complex: receptor I requires receptor II to bind TGF beta; and receptor II requires receptor I to signal. Mutations in TbetaR-I and TbetaR-II gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).
- Gene Details:
- transforming growth factor beta receptor 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide of human TGFbR1
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20°C to -70°C. The antibodies can be stored at 2-8°C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
