Anti-STAT4 Polyclonal Antibody
Product Sizes
100ug
£424.00
OAAI00089-100UG
About this Product
- SKU:
- OAAI00089
- Additional Names:
- signal transducer and activator of transcription 4;signal transducer and activator of transcription 4 variant 3;SLEB11.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- STAT proteins (Signal transducer and activator of transcription) belong to a family of cytoplasmic transcription factors that can be phosphorylated by a lignad binding to its cell surface receptor. Activation of STAT4 induces dimerization; nuclear translocation and DNA binding. STAT4 protein expression is restricted to the thymus; spleen and testis. Both tyrosine and serine residues on STAT4 become phosphorylated in response to IL-12 or IFN-alpha althoμgh serine phosphorylation is not required for DNA binding. STAT4 is activated in T-cells in response to the cytokine interleukin-12 (IL-12); and in NK cells by IL-2. STAT4-deficient mice display impaired IL-12 development of Th1 cells and enhanced development of Th2 cells.
- Gene Details:
- signal transducer and activator of transcription 4
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide surrounding to the C-terminus of STAT4 protein from human. This sequence is identical to mouse; rat; chicken; dog and bovine origins.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
