Anti-NF Kappa Bp65 Antibody
Product Sizes
100ug
£489.00
OAAI00076-100UG
About this Product
- SKU:
- OAAI00076
- Additional Names:
- CMCU;NF-kappa-B p65delta3;NF-kappa-B transcription factor p65;NFKB3;nuclear factor NF-kappa-B p65 subunit;nuclear factor of kappa light polypeptide gene enhancer in B-cells 3;p65;transcription factor p65;v-rel avian reticuloendotheliosis viral oncogene homolog A.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- NFkB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50/NFkB1)) and a 65 kDa transactivation subunit (p65/RelA). Both of these subunits exhibit sequence homology to the proto-oncogene c-Rel. The p50 has an isoform called p49/p52; and both proteins are derived from the amino-terminal of precursor protein p105 and p100. The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor; IkB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS); pro-inflammatory cytokines (IL-1 & TNF; etc.); and viral infection; IkB is phosphorylated and degraded by proteosome. The active NFkB heterodimer is translocated into the nucleus and induces gene expression.The inhibition of p53 activity is dependent upon phosphorylation of p65 (RelA) at S536 by the upstream kinase IKK beta.
- Gene Details:
- RELA proto-oncogene; NF-kB subunit
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the epitope containing a phosphorylation site Ser 536 of human NFkB/p65 protein. This sequence is identical within human and mouse.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
