Anti-NF-kB p105/p50 Antibody
Product Sizes
100ug
£511.00
OAAI00072-100UG
About this Product
- SKU:
- OAAI00072
- Additional Names:
- CVID12;DNA-binding factor KBF1;EBP-1;KBF1;NFkappaB;NF-kappaB;NF-kappa-B1;NF-kappabeta;NF-kB;NF-kB1;NFKB-p105;NFKB-p50;nuclear factor kappa-B DNA binding subunit;nuclear factor NF-kappa-B p105 subunit;nuclear factor NF-kappa-B p50 subunit;nuclear factor of kappa light polypeptide gene enhancer in B-cells 1.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- NfkB is a heterodimer that consists of a 50 kDA DNA binding subunit (p50/NFkB1) and a 65 kDa transactivation subnit (p65/ReIA). Both of these subunits exhibit sequence homology to the proto-oncogene c-Rel. The NF-kB1 gene encodes a 105 kDa protein which can undergo cotranslational processing by teh 26S proteasome to produce a 50 kDa protein. The 105 kDa protein is a Rel protein-specific transcription inhibitor and the 50 kDa protein a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines; oxidant-free radicals; ultraviolet irradiation; and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth.
- Gene Details:
- nuclear factor kappa B subunit 1
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the epitope containing a phosphorylation site 337 human NFkB/p105 protein. This sequence is identical within human and mouse.
- Isotype:
- Rabbit IgG
- Molecular Weight:
- 105&50
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
