Anti-C-Jun Antibody
Product Sizes
100ug
£457.00
OAAI00055-100UG
About this Product
- SKU:
- OAAI00055
- Additional Names:
- activator protein 1;AP1;AP-1;c-Jun;cJUN;enhancer-binding protein AP1;Jun activation domain binding protein;jun oncogene;p39;proto-oncogene cJun;proto-oncogene c-Jun;transcription factor AP-1;v-jun avian sarcoma virus 17 oncogene homolog;v-jun sarcoma virus 17 oncogene homolog.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- c-Jun; also known as AP1; v-Jun or AH119; is a component of the transcription factor AP-1; which binds and activates transcription at TRE/AP-1 elements. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 as well as Thr 91 and Thr93. Extracellular signals including growth factors; transforming oncoproteins and UV irradiation stimulate phosphorylation of c-Jun at Ser63/73 and activate c-Jun-dependent transcription. The MAP kinase homologue SAPK/JNK binds to the amino-terminal region of c-Jun and phosphorylates c-Jun at Ser63/73 and Thr91/93. The phosphorylation of Thr239 is catalysed by The inhibition of GSK3 is not required for the dephosphorylation of Thr239 in response to LPS; and nor is the phosphorylation of Thr91 and Thr93 required for the TPA- or EGF-induced dephosphorylation of Thr239 in fibroblasts. The agonist-induced dephosphorylation of Thr239 may involve a conformational change that exposes Thr239 to dephosphorylation and/or the activation of a Thr239 phosphatase.
- Gene Details:
- Jun proto-oncogene; AP-1 transcription factor subunit
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to the epitope -GETPP-at a phosphorylation site Thr 239 of human c-Jun protein. This sequence is identical within human; rat; mouse; bovine and dog.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
