Anti-ERAB Polyclonal Antibody
Product Sizes
100ug
£424.00
OAAI00011-100UG
About this Product
- SKU:
- OAAI00011
- Additional Names:
- 17b-HSD10;3-hydroxy-2-methylbutyryl-CoA dehydrogenase;3-hydroxyacyl-CoA dehydrogenase type-2;ABAD;AB-binding alcohol dehydrogenase;amyloid-beta peptide binding alcohol dehydrogenase;CAMR;DUPXp11.22;endoplasmic reticulum-associated amyloid beta-peptide-binding protein;ERAB;HADH2;HCD2;HSD10MD;MHBD;mitochondrial ribonuclease P protein 2;mitochondrial RNase P subunit 2;MRPP2;MRX17;MRX31;MRXS10;SCHAD;SDR5C1;short chain L-3-hydroxyacyl-CoA dehydrogenase type 2;short chain type dehydrogenase/reductase XH98G2.
- Clonality:
- Polyclonal
- Concentration:
- 100ug/200ul
- Extra Details:
- Mutations in several genes associated with early onset Alzheimer's result in increased extracellular concentRations of the longer form of the beta-amyloid peptide Ab 1-42 relative to Ab 1-40. It is this longer form of Ab that has been shown to be toxic to neurons and may serve as a catalyst for the aggregation and deposition of Ab to produce the neurotoxic effects associated with senile plaque formation. Using the Ab peptide in a yeast two-hybrid screen; a novel interacting protein designated the endoplasmic reticulum-associated amyloid beta-peptide-binding protein (ERAB)/L-3-hydroxyacyl-CoA dehydrogenase type II has been identified. It is shown to be expressed at high levels in Alzheimer's disease-affected brain.
ERAB may contribute to neuronal dysfunction in Alzheimer's disease. - Gene Details:
- hydroxysteroid 17-beta dehydrogenase 10
- Host:
- Rabbit
- Immunogen:
- A synthetic peptide corresponding to aa 100-116 of human ERAB protein.
- Isotype:
- Rabbit IgG
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- The antibodies are stable for 24 months from date of receipt when stored at -20C to -70C. The antibodies can be stored at 2C-8C for three month without detectable loss of activity. Avoid repeated freezing-thawing cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
