AIF
Product Sizes
100 ul
£786.00
OAAH00022-100UL
About this Product
- SKU:
- OAAH00022
- Additional Names:
- AIF; AUNX1; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; SEMDHL
- Clonality:
- Monoclonal
- Extra Details:
- A key event in the apoptotic process is the opening of the mitochondrial permeability transition pore; an event that is regulated by Bcl-2 family proteins; resulting in the release of several proteins from the mitochondrial intermembrane space. Several of these proteins participate in apoptosis; including cytochrome c; procaspases 2; 3; and 9 and AIF (apoptosis-inducing factor) . AIF was shown to cause DNA fragmentation and chromatin condensation; and to induce the release of cytochrome c and caspase-9 from mitochondria. Bcl-2 overexpression was shown to prevent the release of AIF from mitochondria; but not to block its apoptogenic activity.
- Host:
- Mouse
- Immunogen:
- This Aviva monoclonal antibody is produced by immunizing mice with asynthetic peptide (KLH-coupled) corresponding to residues within the carboxy terminus of AIF.
- Isotype:
- Mouse IgG1
- Molecular Weight:
- 67 kDa
- Protein Details:
- Apoptosis-inducing factor 1; mitochondrial
- Shipping Conditions:
- Dry Ice
- Source:
- Mouse mAb
- Storage Conditions:
- Store the product at -20C. Stable for one year from the date of shipment.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
