GDF5 Antibody
Product Sizes
100 ug
£496.00
OAAF08159-100UG
About this Product
- SKU:
- OAAF08159
- Additional Names:
- BDA1C;BMP14;BMP-14;bone morphogenetic protein 14;Cartilage-derived morphogenetic protein 1;cartilage-derived morphogenetic protein-1;CDMP1;DUPANS;growth/differentiation factor 5;LAP4;LAP-4;lipopolysaccharide-associated protein 4;LPS-associated protein 4;OS5;radotermin;SYM1B;SYNS2.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly; positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A; leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (PubMed:24098149; PubMed:21976273; PubMed:15530414; PubMed:25092592). Secondly; negatively regulates chondrogenic differentiation through its interaction with NOG (PubMed:21976273). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (By similarity). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response; including TNF secretion by monocytes (PubMed:11276205).
- Gene Details:
- growth differentiation factor 5
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from the Internal region of human GDF5.
- Isotype:
- IgG
- Molecular Weight:
- 55 kDa
- Protein Details:
- Growth/differentiation factor 5
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
