XRCC3 Antibody
Product Sizes
100 ug
£496.00
OAAF07902-100UG
About this Product
- SKU:
- OAAF07902
- Additional Names:
- CMM6;DNA repair protein XRCC3;X-ray repair complementing defective repair in Chinese hamster cells 3;X-ray repair cross-complementing protein 3.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA; thought to repair chromosomal fragmentation; translocations and deletions. Part of the RAD21 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage; CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.
- Gene Details:
- X-ray repair cross complementing 3
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human XRCC3.
- Molecular Weight:
- 37 kDa
- Protein Details:
- DNA repair protein XRCC3
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
