MARK1/2/3/4 Antibody
Product Sizes
100 ug
£496.00
OAAF07619-100UG
About this Product
- SKU:
- OAAF07619
- Additional Names:
- cdc25C-associated protein kinase 1;CTAK1;C-TAK1;ELKL motif kinase 1;ELKL motif kinase 2;EMK1;EMK-1;EMK-2;epididymis secretory sperm binding protein;KP78;MAP/microtubule affinity-regulating kinase 1;MAP/microtubule affinity-regulating kinase 2;MAP/microtubule affinity-regulating kinase 3;MAP/microtubule affinity-regulating kinase 4;MAP/microtubule affinity-regulating kinase like 1;MAP/microtubule affinity-regulating kinase-like 1;MARK;MARK4 serine/threonine protein kinase;MARK4L;MARK4S;MARKL1;MARKL1L;PAR-1;PAR1 homolog;PAR1 homolog b;PAR1 homolog c;Par-1a;PAR1A;Par1b;Par-1b;Par1c;Par-1c;PAR-1D;protein kinase STK10;ser/Thr protein kinase PAR-1;Ser/Thr protein kinase PAR-1B;serine/threonine protein kinase EMK;serine/threonine-protein kinase MARK1;serine/threonine-protein kinase MARK2;serine/threonine-protein kinase p78;testicular tissue protein Li 117;VIPB.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Serine/threonine-protein kinase (PubMed:15009667; PubMed:14594945; PubMed:23666762; PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945; PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network; causing reorganization of microtubules into bundles (PubMed:14594945; PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression; specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway; and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex; probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942).|Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2; DCX; HDAC7; KIF13B; MAP2; MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2; MAP4 and MAPT/TAU at KXGS motifs; causing detachment from microtubules; and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics; possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B; promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7; promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway; probably by mediating phosphorylation of dishevelled proteins (DVL1; DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.|Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX; MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2; MAP4 and MAPT/TAU at KXGS motifs; causing detachment from microtubules; and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics; possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway; probably by mediating phosphorylation of dishevelled proteins (DVL1; DVL2 and/or DVL3).|Serine/threonine-protein kinase (PubMed:23666762). Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7; promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus (PubMed:16980613). Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1 (PubMed:28087714).
- Gene Details:
- microtubule affinity regulating kinase 1|microtubule affinity regulating kinase 2|microtubule affinity regulating kinase 3|microtubule affinity regulating kinase 4
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MARK1/2/3/4 around the phosphorylation site of Thr215.
- Isotype:
- IgG
- Molecular Weight:
- 89 kDa
- Protein Details:
- MAP/microtubule affinity-regulating kinase 3|MAP/microtubule affinity-regulating kinase 4|Serine/threonine-protein kinase MARK1|Serine/threonine-protein kinase MARK2
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
